Acetylomics Analysis Service
MtoZ Biolabs offers comprehensive Acetylomics Analysis Service powered by Thermo Fisher Orbitrap Fusion, Q Exactive HF, and Orbitrap Lumos mass spectrometers combined with Nano-LC. Our Acetylomics Analysis Service enables accurate identification of lysine acetylation sites, enrichment of acetylated peptides, quantitative profiling, and advanced bioinformatics analysis. With high-resolution instrumentation and robust workflows, we deliver reproducible data that accelerate research in disease biology, drug discovery, and epigenetics.
Overview
Protein acetylation is a dynamic and reversible post-translational modification that regulates chromatin remodeling, transcriptional activation, protein stability, and metabolic processes. Lysine acetyltransferases (KATs) catalyze the addition of acetyl groups to lysine residues, while histone deacetylases (HDACs) remove them, maintaining cellular homeostasis. Beyond histones, non-histone acetylation affects a wide range of proteins involved in signaling pathways, metabolism, and immune responses. Aberrant acetylation is associated with cancer, cardiovascular disease, neurodegeneration, and immune dysfunction, making acetylomics a powerful tool for mechanistic exploration and therapeutic innovation.
Services at MtoZ Biolabs
MtoZ Biolabs provides a full suite of Acetylomics Analysis Services tailored to diverse research needs:
● Acetylated Peptide Enrichment Service
Antibody-based enrichment strategies selectively capture acetylated peptides, enabling sensitive detection of low-abundance modifications.
● Acetylation Site Identification Service
High-confidence mapping of lysine acetylation sites across histone and non-histone proteins.
● Quantitative Acetylomics Service
Flexible strategies including Label-Free, TMT/iTRAQ, and DIA workflows for dynamic quantification of acetylation under varying biological conditions.
● Acetylomics Data Analysis Service
Advanced bioinformatics pipelines integrating site mapping, quantification, pathway enrichment, and protein interaction networks.
Figure 1. Workflow of Acetylomics Analysis
Why Choose MtoZ Biolabs?
✔ Advanced Instrumentation: Orbitrap MS combined with Nano-LC provides exceptional sensitivity and resolution.
✔ Comprehensive Detection: Reliable coverage of both histone and non-histone acetylation events.
✔ Targeted Antibody-Based Enrichment: Optimized antibody capture methods enhance detection of acetylated peptides.
✔ Flexible Quantification: Multiple workflows including Label-Free, TMT/iTRAQ, and DIA for precise profiling.
✔ Transparent Pricing: One-time charge with no hidden costs.
Sample Submission Suggestions
Note: Provide details on sample collection and handling. If you need further details, our technical support team is happy to assist and provide comprehensive guidance on sample submission.
Applications
Our Acetylomics Analysis Service supports a wide range of research and translational applications:
● Epigenetics and Chromatin Research: Profiling histone acetylation patterns that regulate gene expression.
● Cancer Biology: Exploring dysregulated acetylation in tumor development, progression, and therapy resistance.
● Neurobiology: Investigating acetylation’s role in synaptic plasticity and neurodegenerative diseases.
● Metabolism and Immunology: Characterizing acetylation-mediated regulation of metabolic enzymes and immune signaling.
● Drug Development: Assessing KATs and HDACs as therapeutic targets and identifying acetylation-based biomarkers.
What Could be Included in the Report?
1. Comprehensive Experimental Details
2. Materials, Instruments, and Methods
3. Total Ion Chromatogram & Quality Control Assessment
4. Data Analysis, Preprocessing, and Estimation
5. Bioinformatics Analysis
6. Raw Data Files
Acetylomics Analysis Service provides researchers with reliable data to explore the functional impact of protein acetylation in health and disease. At MtoZ Biolabs, we not only specialize in acetylation profiling but also offer a full portfolio of post-translational modification proteomics services, including phosphorylation, methylation, ubiquitination, succinylation, and more. By integrating multiple PTM-omics platforms, we deliver comprehensive insights into protein regulation and cellular networks. Contact us today to learn how our expertise in PTM-omics can accelerate your research and development programs.